XGEVA® is a prescription medicine used to prevent fracture, spinal cord compression, or the need for radiation or surgery to bone in patients with multiple myeloma and in patients with bone metastases from solid tumors.


Prepare for Your First Shot of XGEVA®

If you and your doctor have decided to start helping prevent serious bone problems* with XGEVA®, you may need some information to prepare for your first shot.1

Here are some tips to help you before, during, and after your first XGEVA® treatment.

*Serious bone problems are defined as broken bones (fractures), the need for surgery to bones, the need for radiation treatments to the bone, and spinal cord compression.1


Checking calcium levels1

Before starting XGEVA®, your doctor will test your blood calcium levels. Levels must be regular in order to start treatment. Your doctor will correct calcium levels if they are too low.

XGEVA® has been shown to cause low blood calcium levels, also known as hypocalcemia (pronounced hi•po•cal•SEE•me•ah), which can be life threatening. Be sure to take calcium and vitamin D as directed by your doctor to help reduce your risk of having this side effect.
Learn more about hypocalcemia


Testing for pregnancy1

Your doctor will check if you are pregnant before you start XGEVA®. Women should use highly effective birth control when taking XGEVA®.

Birth control should be taken for at least 5 months after your last dose of XGEVA®. Tell you doctor if you are pregnant, are planning a pregnancy, think you are pregnant, or are breastfeeding.


Setting up a routine appointment1

Talk to your doctor about setting up an appointment for once every 4 weeks. It is important to be consistent to give yourself the best chance of getting the kind of results seen in the clinical trials.

Think about your schedule and figure out what times and dates work best for you
Learn more about sticking to your treatment schedule


What to wear to your appointment1

When choosing what to wear to your appointment, opt for loose-fitting clothes. Your doctor will choose where you get your shot. So, you will want to pick clothes that can easily make these areas available:

  • Upper arm
  • Upper thigh
  • Stomach area

These are the places XGEVA® can be given as a shot. The area will first be sterilized with rubbing alcohol. After the shot is given, this area will be sterilized again and covered with some cotton and a bandage.


Take care of your teeth1

Inform your doctor of any dental work or if you're having tooth pain before receiving XGEVA®. In clinical studies, osteonecrosis (pronounced os•tee•oh•neh•CROW•sis) of the jaw (ONJ) was reported in some patients taking XGEVA®, which can be very serious.

In clinical studies, serious jaw problems were more common in people with a history of:

  • tooth removal2
  • using a dental appliance (like dentures, fillings, crowns, implants, mouth guards, bridges, braces/retainers, prosthetics, or anything used to open the airways for snoring)1,2
  • poor dental hygiene3

Inform your doctor if you have a history of the things listed above, as your risk of ONJ may go up while taking XGEVA®.1-3

Taking care of your gums and teeth while taking XGEVA® can aid in avoiding ONJ.3

It's also important to visit your dentist as often as they recommend. Let your dentist know that you are taking XGEVA®.1,3
Learn more about ONJ.