FAQs about XGEVA® (denosumab) Injection

XGEVA® is a prescription medicine used to prevent fracture, spinal cord compression, or the need for radiation or surgery to bone in patients with multiple myeloma and in patients with bone metastases from solid tumors.


Frequently Asked Questions About XGEVA®

What is XGEVA®?

XGEVA® is an FDA-approved medicine... More Information

Why would I need to take XGEVA®?

It was shown to help prevent serious bone problems... More Information

How does XGEVA® work?

XGEVA® slows bone breakdown... More Information

How is XGEVA® given and how often?

XGEVA® is a shot given by your doctor. It is different from your cancer treatment... More Information

How can I prepare for my first shot of XGEVA®?

Here are some tips to help you before, during, and after your first XGEVA® treatment... More Information

What if I missed a dose of XGEVA®?

If you've missed a dose, talk to your doctor and healthcare team right away... More Information

What are the side effects of XGEVA®?

For the full list of side effects, see the Important Safety Information section below.

Osteonecrosis of the jaw

In clinical studies of XGEVA® vs ZA, a condition called hypocalcemia (pronounced hi•po•cal•SEE•me•ah, also known as low calcium levels in the blood) was seen... More Information

Unusual thigh bone fracture

Unusual thigh bone fracture was reported in clinical studies of XGEVA®... More Information

After stopping XGEVA®

Risk for breaking bones in the spine may be increased after stopping XGEVA®. If you have a history of broken bones (fractures) or osteoporosis, your risk may be higher... More Information

I'm caring for someone who is taking XGEVA®. How can I help my loved one?

Learn about what can happen when cancer weakens the bone so you can support your loved one… More information

Can I sign up for updates of XGEVA®?

Signing up can help you stay informed about XGEVA®. Go to sign-up page

How do I pay for XGEVA®?

We can refer you to programs that may be able to help you afford your XGEVA® treatment regardless of health insurance. More information on paying for XGEVA®

What are bone metastases from breast, prostate, lung cancer, or other solid tumors?

Bone metastases (pronounced muh•TASS•tuh•seez), or "bone mets," are when cancer cells have spread from the original (primary) tumor to the bone. Bone is a common place for cancer to spread to1.

XGEVA® helped prevent serious bone problems in people with the following types of cancer that had metastasized to the bone:

Breast cancers

Prostate cancers

Other solid tumors (including lung cancer)

What are bone lesions from multiple myeloma?

Multiple myeloma can cause “weak spots”—also called lesions (pronounced LEE•shuns)—in your bones. This can lead to serious bone problems.2-3,*
More Information

*Serious bone problems are defined as broken bones (fractures), the need for surgery to bones, the need for radiation treatments to the bone, and spinal cord compression.4