Staying on XGEVA®

It's Important to Stick to Your XGEVA® Treatment Schedule

Take XGEVA® as prescribed by your doctor

  • Continuing to use XGEVA® as directed by your doctor is an important part of protecting yourself against serious bone problems1*
  • Do not stop treatment with XGEVA® without talking to your doctor first, as your risk for broken bones in your spine can increase. This risk is even higher if you have osteoporosis or have had a prior fracture1
  • Talk to your doctor to see what is right for you
  1. Serious bone problems are defined as broken bones (fractures), the need for surgery to prevent or repair broken bones, the need for radiation treatments to the bone, and pressure on the spinal cord (spinal cord compression).1

What to do if you miss a doseWhat to do if you miss a dose

  • If you have missed a dose, it is important to talk to your doctor and healthcare team for help getting back on track with XGEVA® treatment1
  • Sticking to the treatment schedule your doctor prescribes will help give you the best chance of preventing serious bone problems1

Here are some tips to help you stay on track with your treatment plan:

  • Record appointments in your calendar
  • Schedule future appointments in advance
  • Ask family or friends for help getting to your doctor's office

Important Safety Information

Do not take XGEVA® if you have low blood calcium (hypocalcemia). Your low blood calcium must be treated before you receive XGEVA®. XGEVA® can significantly lower the calcium levels in your blood and some deaths have been reported. Take calcium and vitamin D as your doctor tells you to. Tell your doctor right away if you experience spasms, twitches, cramps, or stiffness in your muscles or numbness or tingling in your fingers, toes, or around your mouth.

Do not take XGEVA® if you are allergic to denosumab or any of the ingredients of XGEVA®. Serious allergic reactions have happened in people who take XGEVA®. Call your doctor or go to your nearest emergency room right away if you have any symptoms of a serious allergic reaction, including low blood pressure (hypotension); trouble breathing; throat tightness; swelling of the face, lips, or tongue, rash; itching; or hives.

What is the most important information you should know about XGEVA®?

Do not take XGEVA® if you take Prolia. XGEVA® contains the same medicine as Prolia® (denosumab).

Severe jaw bone problems (osteonecrosis)

Unusual thigh bone fracture

Risk of high calcium levels in patients with Giant Cell Tumor of Bone and in patients who are still growing

Increased risk of broken bones in the spine after discontinuing XGEVA®

Possible harm to your unborn baby

Tell your doctor if you:

While taking XGEVA®, you should:

What are the possible side effects of XGEVA®?

These are not all the possible side effects of XGEVA®. For more information, ask your doctor or pharmacist.

Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit, or call 1-800-FDA-1088.

Please see Full Prescribing Information.


XGEVA® is a prescription medicine used to prevent fracture, spinal cord compression, or the need for radiation or surgery to bone in patients with multiple myeloma and in patients with bone metastases from solid tumors.

  1. XGEVA® (denosumab) prescribing information, Amgen.