Starting on XGEVA®

Consider XGEVA® NOW To Prevent Serious Bone Problems* Later

XGEVA® helps prevent serious bone problems1

  1. Serious bone problems are defined as broken bones (fractures), the need for surgery to prevent or repair broken bones, the need for radiation treatments to the bone, and pressure on the spinal cord (spinal cord compression).1
  • XGEVA® is a prescription bone-targeting medicine used to prevent serious bone problems* in patients with multiple myeloma and in patients with bone metastases from solid tumors1
  • It’s important to remember to take XGEVA® only as directed by your doctor
  • Talk to your doctor about whether XGEVA® is right for you

How will I receive XGEVA®?XGEVA® is given as a single shot under the skin in upper arm, upper thigh, or abdomen

XGEVA® is given as a shot once every 4 weeks at your doctor's office. The shot is given under the skin and does not involve an infusion through a vein.1

  • XGEVA® can be injected into your upper arm, upper thigh, or stomach area1
  • It is important to take XGEVA® at the recommended treatment schedule1
  • Talk to your doctor about whether scheduling appointments in advance may help with your treatment regimen

What should I know before I start taking XGEVA®?

  • Your doctor will check your blood calcium levels before you start XGEVA®. Low blood calcium must be corrected before you can start your XGEVA® treatments1
  • While you are taking XGEVA®, you may be told to take vitamin D and calcium supplements to help prevent low calcium levels in the blood1
  • Sticking to the treatment schedule your doctor prescribes will help give you the best chance of preventing serious bone problems1
  • Review the Important Safety Information below

Important Safety Information

Do not take XGEVA® if you have low blood calcium (hypocalcemia). Your low blood calcium must be treated before you receive XGEVA®. XGEVA® can significantly lower the calcium levels in your blood and some deaths have been reported. Take calcium and vitamin D as your doctor tells you to. Tell your doctor right away if you experience spasms, twitches, cramps, or stiffness in your muscles or numbness or tingling in your fingers, toes, or around your mouth.

Do not take XGEVA® if you are allergic to denosumab or any of the ingredients of XGEVA®. Serious allergic reactions have happened in people who take XGEVA®. Call your doctor or go to your nearest emergency room right away if you have any symptoms of a serious allergic reaction, including low blood pressure (hypotension); trouble breathing; throat tightness; swelling of the face, lips, or tongue, rash; itching; or hives.

What is the most important information you should know about XGEVA®?

Do not take XGEVA® if you take Prolia. XGEVA® contains the same medicine as Prolia® (denosumab).

Severe jaw bone problems (osteonecrosis)

Unusual thigh bone fracture

Risk of high calcium levels in patients with Giant Cell Tumor of Bone and in patients who are still growing

Increased risk of broken bones in the spine after discontinuing XGEVA®

Possible harm to your unborn baby

Tell your doctor if you:

While taking XGEVA®, you should:

What are the possible side effects of XGEVA®?

These are not all the possible side effects of XGEVA®. For more information, ask your doctor or pharmacist.

Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit, or call 1-800-FDA-1088.

Please see Full Prescribing Information.


XGEVA® is a prescription medicine used to prevent fracture, spinal cord compression, or the need for radiation or surgery to bone in patients with multiple myeloma and in patients with bone metastases from solid tumors.

  1. XGEVA® (denosumab) prescribing information, Amgen.