INDICATION

XGEVA® is a prescription medicine used to prevent fracture, spinal cord compression, or the need for radiation or surgery to bone in patients with multiple myeloma and in patients with bone metastases from solid tumors.

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Understanding Bone Metastases

Cancer begins in one place, and can then spread to the bone1

Bone metastases (pronounced muh•TASS•tuh•seez), or “bone mets,” are when cancer cells have spread from the original (primary) tumor to the bone. Bone is a common place for cancer to spread to.1

*Serious bone problems are defined as:2

How bone metastases from cancer happen

Cancer starts as cells in one part of the body. As the cancer begins to grow, it can spread to other parts of the body.1

Many cancer cells try to spread but die before they can. But, others are able to move to a different part of the body. Once they are there, they can grow.1

Bone is one of the most common locations where cancer spreads. But it can spread to other tissues in the body.1

Bones that most often get metastases1

What can happen when cancer spreads to bone in:

Breast cancer that has spread to the bone can cause serious bone problems. This can happen quickly.3-5

Bone Metastases

Bone is one of the most common spots for advanced metastatic breast cancer to spread6

Of those who developed bone metastases, many suffered a

Serious Bone Problem4

1st SERIOUS BONE PROBLEM

Serious bone problems can happen quickly

people may suffer a serious bone problem after bone metastases diagnosis.4,5

2nd SERIOUS BONE PROBLEM

Once you've had a serious bone problem, you are more likely to have a 2nd one

people may suffer another serious bone problem* within 12 months.7

*Data comes from a study where "serious bone problems" were defined as: spinal cord compression, pathological fracture, surgery to bone, or radiation therapy that was not specific to bone.

Prostate cancer that has spread to the bone can cause serious bone problems. This can happen quickly.5

Bone Metastases

Bone is one of the most common spots for advanced metastatic prostate cancer to spread6

Of those who developed bone metastases, many suffered a

Serious Bone Problem4

1st SERIOUS BONE PROBLEM

Serious bone problems can happen quickly

men may suffer a serious bone problem after bone metastases diagnosis.5

2nd SERIOUS BONE PROBLEM

Once you've had a serious bone problem, you are more likely to have a 2nd one

men may suffer another serious bone problem* within 12 months.9

*Data comes from a study where "serious bone problems" were defined as: spinal cord compression, pathological fracture, surgery to bone, or radiation therapy that was not specific to bone.

Lung cancer that has spread to the bone can cause serious bone problems. This can happen quickly.4,5

Bone Metastases

Bone is one of the most common spots for advanced metastatic lung cancer to spread6

Of those who developed bone metastases, many suffered a

Serious Bone Problem4