Serious Bone Problems

Prevent Serious Bone Problems Before They Occur

Bone mets can cause serious bone problems1

The body constantly rebuilds bones to keep them strong. In a person with bone metastases, or "bone mets," the cells that break down bone may become overactive. This weakens the bone and can lead to serious bone problems.1

Serious bone problems are defined as2:

Fracture to the bone

Broken bones (fractures)

Radiation treatment to the bone

A need for radiation treatments to the bone

Surgery to prevent or repair broken bones

A need for surgery to prevent or repair broken bones

Spinal pressure

Pressure on the spinal cord (spinal cord compression)

Serious bone problems are a common occurrence in patients with bone mets and certain solid tumors

63% of people with breast cancer and bone mets may experience a serious bone problem

and bone mets may experience a serious bone problem3

52% of men with prostate cancer and bone mets may experience a serious bone problem

and bone mets may experience a serious bone problem3

59% of people with lung cancer and bone mets may experience a serious bone problem

and bone mets may experience a serious bone problem3

Early detection of bone mets

Finding bone mets early can help protect your bones from serious bone problems

Early detection of bone mets is important so you can take steps to prevent serious bone problems.1

If you have a bone met from a solid tumor

You can help prevent serious bone problems from bone mets

Whether you're a patient or a caregiver, it's important for you to be informed and proactive about the potential impact of bone mets. What you learn today can make a difference in the future.

Learn how XGEVA® can prevent serious bone problems in patients with bone mets from:

Important Safety Information

Do not take XGEVA® if you have low blood calcium (hypocalcemia). Your low blood calcium must be treated before you receive XGEVA®. XGEVA® can significantly lower the calcium levels in your blood and some deaths have been reported. Take calcium and vitamin D as your doctor tells you to. Tell your doctor right away if you experience spasms, twitches, cramps, or stiffness in your muscles or numbness or tingling in your fingers, toes, or around your mouth.

Do not take XGEVA® if you are allergic to denosumab or any of the ingredients of XGEVA®. Serious allergic reactions have happened in people who take XGEVA®. Call your doctor or go to your nearest emergency room right away if you have any symptoms of a serious allergic reaction, including low blood pressure (hypotension); trouble breathing; throat tightness; swelling of the face, lips, or tongue, rash; itching; or hives.

What is the most important information you should know about XGEVA®?

XGEVA® contains the same medicine as Prolia® (denosumab). If you are taking XGEVA® do not take Prolia®.

Severe jaw bone problems (osteonecrosis)

Unusual thigh bone fracture

Risk of high calcium levels in patients who are still growing

Possible harm to your unborn baby

Tell your doctor if you:

While taking XGEVA®, you should:

What are the possible side effects of XGEVA®?

These are not all the possible side effects of XGEVA®. For more information, ask your doctor or pharmacist.

Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see Full Prescribing Information.

Indication and Limitation of Use

XGEVA® is a prescription medicine used to prevent fracture, spinal cord compression, or the need for radiation or surgery to bone in patients with bone metastases from solid tumors.

XGEVA® is not used to prevent these bone problems in patients with multiple myeloma.

References:
  1. American Cancer Society. Bone metastasis. American Cancer Society website. https://www.cancer.org/content/cancer/en/treatment/understanding-your-diagnosis/advanced-cancer.html. Revised May 2, 2016. Accessed June 5, 2017.
  2. XGEVA® (denosumab) prescribing information, Amgen.
  3. Oster G, Lamerato L, Glass AG, et al. Natural history of skeletal-related events in patients with breast, lung, or prostate cancer and metastases to bone: a 15-year study in two large US health systems. Support Care Cancer. 2013;21(12):3279-3286.