Prostate cancer and serious bone problems

Prostate Cancer

My Prostate Cancer Has Spread to My Bones But
I’m Not Ready to Buckle

XGEVA® helps protect against serious bone problems1

XGEVA® is a prescription medicine used to prevent serious bone problems in patients with bone metastases from solid tumors.1

Serious bone problems are defined as1:

  • Broken bones (fractures)
  • The need for bone surgery
  • Radiation treatments for bone pain
  • Pressure on the spinal cord (spinal cord compression)

For people with bone metastases from prostate cancer,

XGEVA® helps provide the protection you seek from serious bone problems1

In this study, XGEVA® delayed serious bone problems for

20.7months

This was 3.6 months longer than another bone-targeting medicine, zoledronic acid, also known as ZA (17.1 months)1,2*

18% lower chance of serious bone problems with XGEVA than with zoledronic acid

less likely to have serious bone problems with XGEVA® than with ZA1,2*

  1. In a study of 1,901 patients with bone metastases from prostate cancer.1

Explore XGEVA® in other cancer types

Important Safety Information


Do not take XGEVA® if you have low blood calcium (hypocalcemia). Your low blood calcium must be treated before you receive XGEVA®. XGEVA® can significantly lower the calcium levels in your blood and some deaths have been reported. Take calcium and vitamin D as your doctor tells you to. Tell your doctor right away if you experience spasms, twitches, cramps, or stiffness in your muscles or numbness or tingling in your fingers, toes, or around your mouth.

Do not take XGEVA® if you are allergic to denosumab or any of the ingredients of XGEVA®. Serious allergic reactions have happened in people who take XGEVA®. Call your doctor or go to your nearest emergency room right away if you have any symptoms of a serious allergic reaction, including low blood pressure (hypotension); trouble breathing; throat tightness; swelling of the face, lips, or tongue, rash; itching; or hives.

What is the most important information you should know about XGEVA®?

Do not take XGEVA® if you take Prolia. XGEVA® contains the same medicine as Prolia® (denosumab).

Severe jaw bone problems (osteonecrosis)

Unusual thigh bone fracture

Risk of high calcium levels in patients who are still growing

Increased risk of broken bones in the spine after discontinuing XGEVA®

Possible harm to your unborn baby

Tell your doctor if you:

While taking XGEVA®, you should:

What are the possible side effects of XGEVA®?

These are not all the possible side effects of XGEVA®. For more information, ask your doctor or pharmacist.

Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see Full Prescribing Information.

Indication

XGEVA® is a prescription medicine used to prevent fracture, spinal cord compression, or the need for radiation or surgery to bone in patients with multiple myeloma and in patients with bone metastases from solid tumors.

References:
  1. XGEVA® (denosumab) prescribing information, Amgen.
  2. Fizazi K, Carducci M, Smith M, et al. Denosumab versus zoledronic acid for treatment of bone metastases in men with castration-resistant prostate cancer: a randomised, double-blind study. Lancet. 2011;377(9768):813-822.