Impact of Bone Lesions

Learn What Can Happen When Bone Lesions from multiple myeloma impact your bones1,2

What are bone lesions?

Multiple myeloma is a type of cancer that can cause “weak spots”—also called lesions (LEE•shuns)—in your bones. This can lead to serious bone problems.1,2*

  1. Serious bone problems are defined as broken bones (fractures), the need for surgery to prevent or repair broken bones, the need for radiation treatments to the bone, and pressure on the spinal cord (spinal cord compression).3

How do bone lesions from multiple myeloma happen?

Multiple Myeloma and Bone Health

Normally, your body is continually breaking down and rebuilding bone. This helps keep your bones strong.4,5

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Multiple Myeloma’s Effect on Bones

With multiple myeloma, the breakdown and rebuilding of your bones can become unbalanced.1,4

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Multiple Myeloma Bone Lesions

Over time, this can cause weak spots in the bones and can lead to serious bone problems.1,4

Many people with multiple myeloma are at risk for bone lesions6

  • 9 out of 10

    people with MULTIPLE MYELOMA

    will develop bone lesions over time6

Bone lesions are the main cause of serious bone problems1

Important Safety Information


Do not take XGEVA® if you have low blood calcium (hypocalcemia). Your low blood calcium must be treated before you receive XGEVA®. XGEVA® can significantly lower the calcium levels in your blood and some deaths have been reported. Take calcium and vitamin D as your doctor tells you to. Tell your doctor right away if you experience spasms, twitches, cramps, or stiffness in your muscles or numbness or tingling in your fingers, toes, or around your mouth.

Do not take XGEVA® if you are allergic to denosumab or any of the ingredients of XGEVA®. Serious allergic reactions have happened in people who take XGEVA®. Call your doctor or go to your nearest emergency room right away if you have any symptoms of a serious allergic reaction, including low blood pressure (hypotension); trouble breathing; throat tightness; swelling of the face, lips, or tongue, rash; itching; or hives.

What is the most important information you should know about XGEVA®?

Do not take XGEVA® if you take Prolia. XGEVA® contains the same medicine as Prolia® (denosumab).

Severe jaw bone problems (osteonecrosis)

Unusual thigh bone fracture

Risk of high calcium levels in patients who are still growing

Increased risk of broken bones in the spine after discontinuing XGEVA®

Possible harm to your unborn baby

Tell your doctor if you:

While taking XGEVA®, you should:

What are the possible side effects of XGEVA®?

These are not all the possible side effects of XGEVA®. For more information, ask your doctor or pharmacist.

Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see Full Prescribing Information.

Indication

XGEVA® is a prescription medicine used to prevent fracture, spinal cord compression, or the need for radiation or surgery to bone in patients with multiple myeloma and in patients with bone metastases from solid tumors.

References:
  1. Heusschen R, Muller J, Duray E, et al. Molecular mechanisms, current management and next generation therapy in myeloma bone disease. Leuk Lymphoma. 2018;59(1):14-28.
  2. Kyle RA, Gertz MA, Witzig TE, et al. Review of 1027 patients with newly diagnosed multiple myeloma. Mayo Clin Proc. 2003;78(1):21-33.
  3. XGEVA® (denosumab) prescribing information, Amgen.
  4. Roodman GD, Dougall WC. RANK ligand as a therapeutic target for bone metastases and multiple myeloma. Cancer Treat Rev. 2008;34(1):92-101.
  5. American Cancer Society. Understanding advanced cancer, metastatic cancer, and bone metastasis website. https://www.cancer.org/treatment/understanding-your-diagnosis/advanced-cancer/what-is.html. Revised December 15, 2016. Accessed April 30, 2018.
  6. Roodman GD. Pathogenesis of myeloma bone disease. Leukemia. 2009;23(3):435-441.