How XGEVA® Works

XGEVA® PREVENTS THE BREAKDOWN of Bone Destruction

How does XGEVA® work?

Healthy bone

Normally, your body is continually breaking down and rebuilding your bone. This helps keep your bones strong.1

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Cancer spreads to bone

When cancer spreads to bone, your bone breakdown and bone building are not balanced.1

Over time, this can make bones weak and can lead to serious bone problems.1*

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XGEVA prevents serious bone problems

XGEVA® works by stopping cells that are breaking down bone from becoming overactive and may interrupt the process of bone breakdown.2-4

  1. Serious bone problems are defined as broken bones (fractures), the need for surgery to prevent or repair broken bones, the need for radiation treatments to the bone, and pressure on the spinal cord (spinal cord compression).2

Important Safety Information


Do not take XGEVA® if you have low blood calcium (hypocalcemia). Your low blood calcium must be treated before you receive XGEVA®. XGEVA® can significantly lower the calcium levels in your blood and some deaths have been reported. Take calcium and vitamin D as your doctor tells you to. Tell your doctor right away if you experience spasms, twitches, cramps, or stiffness in your muscles or numbness or tingling in your fingers, toes, or around your mouth.

Do not take XGEVA® if you are allergic to denosumab or any of the ingredients of XGEVA®. Serious allergic reactions have happened in people who take XGEVA®. Call your doctor or go to your nearest emergency room right away if you have any symptoms of a serious allergic reaction, including low blood pressure (hypotension); trouble breathing; throat tightness; swelling of the face, lips, or tongue, rash; itching; or hives.

What is the most important information you should know about XGEVA®?

Do not take XGEVA® if you take Prolia. XGEVA® contains the same medicine as Prolia® (denosumab).

Severe jaw bone problems (osteonecrosis)

Unusual thigh bone fracture

Risk of high calcium levels in patients who are still growing

Increased risk of broken bones in the spine after discontinuing XGEVA®

Possible harm to your unborn baby

Tell your doctor if you:

While taking XGEVA®, you should:

What are the possible side effects of XGEVA®?

These are not all the possible side effects of XGEVA®. For more information, ask your doctor or pharmacist.

Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see Full Prescribing Information.

Indication

XGEVA® is a prescription medicine used to prevent fracture, spinal cord compression, or the need for radiation or surgery to bone in patients with multiple myeloma and in patients with bone metastases from solid tumors.

References:
  1. American Cancer Society. Understanding advanced cancer, metastatic cancer, and bone metastasis. American Cancer Society website. https://www.cancer.org/treatment/understanding-your-diagnosis/advanced-cancer/what-is.html. Revised December 16, 2016. Accessed March 6, 2018.
  2. XGEVA® (denosumab) prescribing information, Amgen.
  3. Mundy GR. Metastasis to bone: causes, consequences and therapeutic opportunities. Nat Rev Cancer. 2002;2(8):584-593.
  4. Roodman GD. Mechanisms of bone metastasis. N Engl J Med. 2004;350(16):1655-1664.